{"id":1051,"date":"2026-01-29T15:15:20","date_gmt":"2026-01-29T15:15:20","guid":{"rendered":"https:\/\/biovantixlab.com\/?post_type=product&#038;p=1051"},"modified":"2026-08-17T03:09:56","modified_gmt":"2026-08-17T03:09:56","slug":"epithalon-epitalon-10mg","status":"publish","type":"product","link":"https:\/\/md.biovantixlab.com\/?product=epithalon-epitalon-10mg","title":{"rendered":"Epithalon  10mg"},"content":{"rendered":"\t\t<div data-elementor-type=\"product-post\" data-elementor-id=\"1051\" class=\"elementor elementor-1051\" data-elementor-post-type=\"product\">\n\t\t\t\t<div class=\"elementor-element elementor-element-631530f e-con-full e-flex e-con e-parent\" data-id=\"631530f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6409263 e-n-tabs-mobile elementor-widget elementor-widget-n-tabs\" data-id=\"6409263\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;tabs_justify_horizontal&quot;:&quot;start&quot;,&quot;horizontal_scroll&quot;:&quot;disable&quot;}\" data-widget_type=\"nested-tabs.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"104895075\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-1048950751\" data-tab-title-id=\"e-n-tab-title-1048950751\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-1048950751\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tDescription\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1048950752\" data-tab-title-id=\"e-n-tab-title-1048950752\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1048950752\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\t3RD PARTY TESTING\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-1048950753\" data-tab-title-id=\"e-n-tab-title-1048950753\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-1048950753\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tStorage\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-1048950751\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1048950751\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-897d6be e-con-full e-flex e-con e-child\" data-id=\"897d6be\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-44b9fba e-flex e-con-boxed e-con e-child\" data-id=\"44b9fba\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b926133 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"b926133\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#1\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><span>1. <\/span>What is Epithalon?<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#2\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><span>2. <\/span>Epithalon Structure<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-971ce9b elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"971ce9b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#3\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><span>3. <\/span>Epithalon Research<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#4\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><span>4. <\/span>Referenced Citations<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a49f79b e-flex e-con-boxed e-con e-child\" data-id=\"a49f79b\" data-element_type=\"container\" data-e-type=\"container\" id=\"1\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8d0502c e-con-full e-flex e-con e-child\" data-id=\"8d0502c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59aaf24 elementor-widget elementor-widget-heading\" data-id=\"59aaf24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">What Is Epithalon?\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ee5a12a e-con-full e-flex e-con e-child\" data-id=\"ee5a12a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b63b42 elementor-widget elementor-widget-text-editor\" data-id=\"7b63b42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\tEpithalon (also known as Epitalon, Epithalone or Epithalamin) is a short synthetic peptide known to activate the telomerase enzyme and stimulate melatonin release. First developed in Russia in the 1980s, epithalon has been shown to delay age-related changes in reproductive and immune systems and increase the life span of mice and rats. Though it is primarily of interest in anti-aging research, epithalon has shown significant effects in certain types of cancer, infectious disease, and in DNA regulation.\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-805a397 e-flex e-con-boxed e-con e-child\" data-id=\"805a397\" data-element_type=\"container\" data-e-type=\"container\" id=\"2\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e03ab05 e-con-full e-flex e-con e-child\" data-id=\"e03ab05\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1eea56f elementor-widget elementor-widget-heading\" data-id=\"1eea56f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Epithalon Structure\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c9269a6 e-con-full e-flex e-con e-child\" data-id=\"c9269a6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-313789c elementor-widget elementor-widget-text-editor\" data-id=\"313789c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Sequence:<\/strong>\u00a0Ala-Glu-Asp-Gly<br \/><strong>Molecular Formula:<\/strong>\u00a0C<sub>14<\/sub>H<sub>22<\/sub>N<sub>4<\/sub>O<sub>9<\/sub><br \/><strong>Molecular Weight:<\/strong>\u00a0390.349 g\/mol<br \/><strong>PubChem CID:<\/strong>\u00a0219042<br \/><strong>CAS Number:<\/strong>\u00a0307297-39-8<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f617e17 elementor-widget elementor-widget-image\" data-id=\"f617e17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-structure.png\" class=\"attachment-full size-full wp-image-254\" alt=\"\" srcset=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-structure.png 300w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-structure-150x150.png 150w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-structure-100x100.png 100w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-78acb31 elementor-widget elementor-widget-text-editor\" data-id=\"78acb31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><p>Source:\u00a0<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/219042\" target=\"_blank\" rel=\"nofollow noopener\">PubChem<\/a><\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-89a922c e-flex e-con-boxed e-con e-child\" data-id=\"89a922c\" data-element_type=\"container\" data-e-type=\"container\" id=\"3\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f5455f0 e-con-full e-flex e-con e-child\" data-id=\"f5455f0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd6fbb4 elementor-widget elementor-widget-heading\" data-id=\"dd6fbb4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Epithalon Research\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc49a3c e-con-full e-flex e-con e-child\" data-id=\"cc49a3c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f48ec5c elementor-widget elementor-widget-text-editor\" data-id=\"f48ec5c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><h3>1. The Role of Telomerase in the Anti-Aging Effects of Epithalon<\/h3><p>Early research using insects and rodents revealed that epithalon can prolong life substantially. In normal, healthy fruit flies and rats, epithalon decreases mortality by 52%. In mice prone to both heart disease and cancer, epithalon prolongs life by as much as 27% compared to controls<sup>[<a title=\"V. N. Anisimov, S. V. Mylnikov, and V. K. Khavinson, \u201cPineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,\u201d Mech. Ageing Dev., vol. 103, no. 2, pp. 123\u2013132, Jun. 1998.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">1<\/a>]<\/sup>. At least part of the answer to how epithalon achieves these profound effects is via its elimination of free radicals (charged molecules that do damage to healthy tissue).<\/p><p>Anti-oxidant activity is not the only reason that epithalon extends life, however. There is good evidence from in vitro experiments on human somatic cells to show that epithalon activates an enzyme called telomerase<sup>[<a title=\"V. K. Khavinson, I. E. Bondarev, and A. A. Butyugov, \u201cEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells,\u201d Bull. Exp. Biol. Med., vol. 135, no. 6, pp. 590\u2013592, Jun. 2003.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">2<\/a>]<\/sup>. Telomerase protects telomeres, the ends of chromosomes that are critical to ensuring the health of DNA. Epithalon\u2019s activation of telomerase leads directly to a decrease in how many errors a strand of DNA contains, supporting the notion that epithalon protects DNA from damage<sup>[<a title=\"VT. A. Dzhokhadze, T. Z. Buadze, M. N. Gaiozishvili, M. A. Rogava, and T. A. Lazhava, \u201c[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)],\u201d Georgian Med. News, no. 225, pp. 94\u201397, Dec. 2013.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">3<\/a>], [<a title=\"V. N. Anisimov et al., \u201cEffect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,\u201d Biogerontology, vol. 4, no. 4, pp. 193\u2013202, 2003.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">4<\/a>]<\/sup>. In short, epithalon protects DNA from accumulating errors over time, a process that eventually leads to cell dysfunction, aging, and even cancer in some cases.<\/p><h3>2. Epithalon and DNA Activation<\/h3><p>Neither its impact on free radicals nor its effects on telomeres seem sufficient to explain the profound effects that epithalon has on longevity. Indeed, scientists are working hard to understand how this short peptide achieves the effects that it does so that the mechanisms can be explored in depth. As it turns out, at least part of the answer may come from the fact that epithalon changes the expression of certain genes.<\/p><p>Research in cell cultures shows that epithalon interacts directly with DNA to turn on and enhance the expression of certain genes. Epithalon interacts with the promoter regions of genes for CD5, IL-2, MMP2, and Tram1<sup>[<a title=\"V. K. Khavinson, S. I. Tarnovskaya, N. S. Linkova, V. E. Pronyaeva, L. K. Shataeva, and P. P. Yakutseni, \u201cShort cell-penetrating peptides: a model of interactions with gene promoter sites,\u201d Bull. Exp. Biol. Med., vol. 154, no. 3, pp. 403\u2013410, Jan. 2013.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">5<\/a>]<\/sup>. CD5 and IL-2 both affect the function of the immune system while MMP2 plays a critical role in the maintenance of extracellular matrix in skin, tendons, and other connective tissue. These findings suggest that epithalon may impact the function of the immune system and the ability of the body to heal itself following not only injury, but following typical day-to-day stress as well.<\/p><p>It is not surprising that epithalon impacts the immune system. Research in rats indicates that epithalon boost the expression of interferon gamma in aging lymphocytes<sup>[<a title=\"N. S. Lin\u2019kova, B. I. Kuznik, and V. K. Khavinson, \u201c[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 25, no. 3, pp. 478\u2013482, 2012.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">6<\/a>]<\/sup>. Interferon gamma is a critical signaling molecule in the immune system. It is important for fighting off viral infections through the activation of macrophages, natural killer cells, and T cells.<\/p><p>The following are known DNA interactions of epithalon:<\/p><ol><li>CD5 \u2013 Leads to immune cell differentiation<\/li><li>IL-2 \u2013 Increases IL-2 production, which regulates white blood cells<\/li><li>MMP2 \u2013 Enhances MMP activation and decreases inflammation<\/li><li>Tram1 \u2013 Enhances protein production<\/li><li>Arylalkylamine-N-acetyltransferase \u2013 Enhances melatonin production<\/li><li>pCREB t \u2013 Circadian rhythm regulation and anti-neoplastic effects<\/li><li>Telomerase \u2013 Telomerase activity increases cell longevity<\/li><\/ol><h3>3. Epithalon and Skin Health<\/h3><p>As stated above, epithalon has a positive effect on the gene that regulates MMP2. MMP2 is a protein found in connective tissue like skin. Research in rodents indicates that not only does epithalon activate this gene, it activates fibroblasts, the cells that produce and maintain MMP2 as well as other components of the extracellular matrix like collagen and elastin. Mice exposed to epithalon show an increase in fibroblast activation of 30-45%<sup>[<a title=\"N. I. Chalisova, N. S. Lin\u2019kova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. K. Khavinson, \u201c[Short peptides stimulate skin cell regeneration during ageing],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 27, no. 4, pp. 699\u2013703, 2014.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">7<\/a>]<\/sup>. By activating fibroblasts, epithalon can help to boost rates of healing and offset the natural decline in skin structure and integrity that occurs with aging.<\/p><p>Further evidence for epithalon\u2019s benefit in skin comes from the fact that it decreases caspase-3 activity. Caspase-3 is an enzyme in the apoptosis or programmed cell death pathway. By decreasing caspase-3 activity, epithalon helps to protect fibroblasts and other skin cells, keeping them alive and healthy for longer periods of time<sup>[<a title=\"N. S. Lin\u2019kova et al., \u201cPeptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro,\u201d Bull. Exp. Biol. Med., vol. 161, no. 1, pp. 175\u2013178, May 2016.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">8<\/a>]<\/sup>.<\/p><h3>4. Epithalon and Tumor Growth<\/h3><p>Daily administration of epithalon to rats with cancer has been found to decrease tumor growth<sup>[<a title=\"I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, \u201cEffect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes,\u201d Bull. Exp. Biol. Med., vol. 144, no. 6, pp. 825\u2013830, Dec. 2007.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">9<\/a>]<\/sup>. Not only does the peptide reduce tumor growth, it prevents the metastasis or spread of these tumors to distant tissues as well<sup>[<a title=\"G. Kossoy, V. N. Anisimov, H. Ben-Hur, N. Kossoy, and I. Zusman, \u201cEffect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H\/He mice,\u201d Vivo Athens Greece, vol. 20, no. 2, pp. 253\u2013257, Apr. 2006.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">10<\/a>], [<a title=\"V. N. Anisimov et al., \u201cInhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2\/neu transgenic mice,\u201d Int. J. Cancer, vol. 101, no. 1, pp. 7\u201310, 2002.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">11<\/a>]<\/sup>. Epithalon is currently being investigated as a potential treatment for Her-2\/neu positive breast cancers and is of interest in preventing the development of certain types of leukemia as well as testicular cancer<sup>[<a title=\"V. N. Anisimov, V. K. Khavinson, I. N. Alimova, A. V. Semchenko, and A. I. Yashin, \u201cEpithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2\/neu mice,\u201d Bull. Exp. Biol. Med., vol. 134, no. 2, pp. 187\u2013190, Aug. 2002.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">12<\/a>], [<a title=\"I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, \u201cGeroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens,\u201d Bull. Exp. Biol. Med., vol. 145, no. 4, pp. 472\u2013477, Apr. 2008.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">13<\/a>]<\/sup>.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37d8f0d elementor-widget elementor-widget-image\" data-id=\"37d8f0d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"500\" height=\"350\" src=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-chart1.gif\" class=\"attachment-large size-large wp-image-253\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fb0a45 elementor-widget elementor-widget-text-editor\" data-id=\"8fb0a45\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><p>Slowed tumor growth in mice exposed to epithalon compared to controls<br \/>Source:\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ijc.10570?sid=nlm%3Apubmed\" target=\"_blank\" rel=\"nofollow noopener\">Wiley Online Library<\/a><\/p><p>There is some evidence that epithalon activates the gene for PER1 protein, which is found in the hypothalamus. PER1, which helps to regulate circadian rhythm, is under-expressed in cancer patients. It is unclear if this under-expression precedes cancer development and therefore contributes to cancer growth or is a consequence of cancer development. It is clear that the protein affects cancer growth once the cancer is established. Control of PER1 expression may be one means of naturally slowing tumor growth. Research shows that PER1 expression sensitizes cells to the effects of radiation and may therefore help to decrease the doses of radiation needed to treat certain cancers, a fact that would not only offset immediate side effects, but reduce the occurrence of secondary tumors following high doses of radiation<sup>[<a title=\"S. Gery, N. Komatsu, L. Baldjyan, A. Yu, D. Koo, and H. P. Koeffler, \u201cThe circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells,\u201d Mol. Cell, vol. 22, no. 3, pp. 375\u2013382, May 2006.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">14<\/a>]<\/sup>.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c5a9a9 elementor-widget elementor-widget-image\" data-id=\"9c5a9a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"228\" height=\"155\" src=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/epithalon-chart2.png\" class=\"attachment-large size-large wp-image-252\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e1a39f elementor-widget elementor-widget-text-editor\" data-id=\"9e1a39f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><p>PER1 Causes Increased Rates of Ionizing Radiation-Induced Cell Death<br \/>Source:\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.molcel.2006.03.038\" target=\"_blank\" rel=\"nofollow noopener\">Molecular Cell<\/a><\/p><h3>5. Epithalon and Melatonin Secretion<\/h3><p>Melatonin, which is linked to sleep and aging, is produced by the pineal gland. Research in rats shows that epithalon and similar peptides affect both the synthesis and release of melatonin by affecting the expression of two proteins (arylalkylamine-N-acetyltransferase (AANAT) and pCREB transcription protein)<sup>[<a title=\"SV. K. Khavinson, L. K. Shataeva, and A. A. Chernova, \u201cEffect of regulatory peptides on gene transcription,\u201d Bull. Exp. Biol. Med., vol. 136, no. 3, pp. 288\u2013290, Sep. 2003.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">15<\/a>]<\/sup>.Both of these genes play an important role in melatonin production and in the circadian (day\/night) control of melatonin release. Research in monkeys indicates that epithalon restores melatonin secretion to normal<sup>[<a title=\"O. V. Korkushko et al., \u201c[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 20, no. 1, pp. 74\u201385, 2007.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">16<\/a>]<\/sup>.<\/p><h3>6. Epithalon and Eyesight<\/h3><p>A trial in rats suffering from retinitis pigmentosa found that epithalon improves outcomes in 90% of patients<sup>[<a title=\"V. Khavinson, M. Razumovsky, S. Trofimova, R. Grigorian, and A. Razumovskaya, \u201cPineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa,\u201d Neuro Endocrinol. Lett., vol. 23, no. 4, pp. 365\u2013368, Aug. 2002.\" href=\"https:\/\/www.peptidesciences.com\/epithalon-epitalon?size=50mg#resources\">17<\/a>]<\/sup>. It appears that the peptide helps to preserver normal structure of the eye while boosting the bioelectric function of the retina necessary for vision.<\/p><p>Epithalon exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans.\u00a0Epithalon for sale at Peptide Sciences is limited to educational and scientific research only, not for human consumption. Only buy\u00a0Epithalon if you are a licensed researcher.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-26183fd elementor-widget elementor-widget-video\" data-id=\"26183fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/TeqO3tdR3M8&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8f12065 e-flex e-con-boxed e-con e-child\" data-id=\"8f12065\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-67de5a3 e-con-full e-flex e-con e-child\" data-id=\"67de5a3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-49efd74 elementor-widget elementor-widget-heading\" data-id=\"49efd74\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Article Author\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fddb75a e-con-full e-flex e-con e-child\" data-id=\"fddb75a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d874b6d elementor-widget elementor-widget-text-editor\" data-id=\"d874b6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><p>The above literature was researched, edited and organized by Dr. E. Logan, M.D. Dr. E. Logan holds a doctorate degree from\u00a0<a href=\"https:\/\/case.edu\/medicine\/\" target=\"_blank\" rel=\"nofollow noopener\">Case Western Reserve University School of Medicine<\/a> and a B.S. in molecular biology.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-855637d e-flex e-con-boxed e-con e-child\" data-id=\"855637d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3657e2d e-con-full e-flex e-con e-child\" data-id=\"3657e2d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-902f324 elementor-widget elementor-widget-heading\" data-id=\"902f324\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Scientific Journal Author\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e8875f e-con-full e-flex e-con e-child\" data-id=\"5e8875f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f61bc90 elementor-widget elementor-widget-image\" data-id=\"f61bc90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"100\" height=\"100\" src=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/khavison-v.png\" class=\"attachment-full size-full wp-image-202\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c7829a1 elementor-widget elementor-widget-text-editor\" data-id=\"c7829a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><p><a href=\"http:\/\/khavinson.info\/curriculum-vitae\" target=\"_blank\" rel=\"nofollow noopener\"><strong>Vladimir Khavinson<\/strong><\/a>\u00a0is a Professor, President of the European region of the\u00a0International Association of Gerontology and Geriatrics; Member of the\u00a0<a class=\"new\" title=\"Russian and Ukrainian Academies of Medical Sciences (page does not exist)\" href=\"https:\/\/en.wikipedia.org\/w\/index.php?title=Russian_and_Ukrainian_Academies_of_Medical_Sciences&amp;action=edit&amp;redlink=1\" rel=\"nofollow\">Russian and Ukrainian Academies of Medical Sciences<\/a>; Main gerontologist of the Health Committee of the Government of\u00a0Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice-president of Gerontological Society of the\u00a0<a title=\"Russian Academy of Sciences\" href=\"https:\/\/en.wikipedia.org\/wiki\/Russian_Academy_of_Sciences\" rel=\"nofollow\">Russian Academy of Sciences<\/a>; Head of the Chair of Gerontology and Geriatrics of the\u00a0North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired.\u00a0Vladimir Khavinson is known for the discovery, experimental and clinical studies of new classes of\u00a0<a title=\"Peptide\" href=\"https:\/\/en.wikipedia.org\/wiki\/Peptide\" rel=\"nofollow\">peptide<\/a>\u00a0bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying of the role of peptides in regulation of the mechanisms of ageing. His main field of actions is design, pre-clinical and clinical studies of new peptide\u00a0<a title=\"Geroprotector\" href=\"https:\/\/en.wikipedia.org\/wiki\/Geroprotector\" rel=\"nofollow\">geroprotectors<\/a>. A 40-year-long investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of ageing and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications.\u00a0His major achievements are presented in two books: \u201cPeptides and Ageing\u201d (NEL, 2002)\u00a0and \u201cGerontological aspects of genome peptide regulation\u201d (Karger AG, 2005).\u00a0Vladimir Khavinson introduced scientific specialty &#8220;Gerontology and Geriatrics&#8221; in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversighted over 200 Ph.D. and Doctorate theses from many different countries.<\/p><p>Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Chonluten. In no way is this doctor\/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Sciences and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Prof. Vladimir Khavinson is listed in [1] [2] [4] [5] [6] and [7] under the referenced citations.<\/p><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40ba7b7 e-flex e-con-boxed e-con e-child\" data-id=\"40ba7b7\" data-element_type=\"container\" data-e-type=\"container\" id=\"4\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fa5e150 e-con-full e-flex e-con e-child\" data-id=\"fa5e150\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d98030c elementor-widget elementor-widget-heading\" data-id=\"d98030c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Referenced Citations\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2f740c1 e-con-full e-flex e-con e-child\" data-id=\"2f740c1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1c1164 elementor-widget elementor-widget-text-editor\" data-id=\"d1c1164\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"product.info.description\" class=\"product-tab-content\" role=\"tabpanel\" aria-labelledby=\"tab-label-product.info.description\" data-role=\"content\" aria-hidden=\"false\"><div class=\"l-page__container description\"><div class=\"c-pdp-contents__item\"><div class=\"c-pdp-contents__text\"><ol><li>V. N. Anisimov, S. V. Mylnikov, and V. K. Khavinson, \u201cPineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,\u201d Mech. Ageing Dev., vol. 103, no. 2, pp. 123\u2013132, Jun. 1998. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9701766\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. K. Khavinson, I. E. Bondarev, and A. A. Butyugov, \u201cEpithalon peptide induces telomerase activity and telomere elongation in human somatic cells,\u201d Bull. Exp. Biol. Med., vol. 135, no. 6, pp. 590\u2013592, Jun. 2003. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12937682\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>T. A. Dzhokhadze, T. Z. Buadze, M. N. Gaiozishvili, M. A. Rogava, and T. A. Lazhava, \u201c[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)],\u201d Georgian Med. News, no. 225, pp. 94\u201397, Dec. 2013. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24423684\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. N. Anisimov et al., \u201cEffect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,\u201d Biogerontology, vol. 4, no. 4, pp. 193\u2013202, 2003. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14501183\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. K. Khavinson, S. I. Tarnovskaya, N. S. Linkova, V. E. Pronyaeva, L. K. Shataeva, and P. P. Yakutseni, \u201cShort cell-penetrating peptides: a model of interactions with gene promoter sites,\u201d Bull. Exp. Biol. Med., vol. 154, no. 3, pp. 403\u2013410, Jan. 2013. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23484211\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>N. S. Lin\u2019kova, B. I. Kuznik, and V. K. Khavinson, \u201c[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 25, no. 3, pp. 478\u2013482, 2012. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23289226\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>N. I. Chalisova, N. S. Lin\u2019kova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. K. Khavinson, \u201c[Short peptides stimulate skin cell regeneration during ageing],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 27, no. 4, pp. 699\u2013703, 2014. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25946846\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>N. S. Lin\u2019kova et al., \u201cPeptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro,\u201d Bull. Exp. Biol. Med., vol. 161, no. 1, pp. 175\u2013178, May 2016. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27259496\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, \u201cEffect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes,\u201d Bull. Exp. Biol. Med., vol. 144, no. 6, pp. 825\u2013830, Dec. 2007. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18856211\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>G. Kossoy, V. N. Anisimov, H. Ben-Hur, N. Kossoy, and I. Zusman, \u201cEffect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H\/He mice,\u201d Vivo Athens Greece, vol. 20, no. 2, pp. 253\u2013257, Apr. 2006. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16634527\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. N. Anisimov et al., \u201cInhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2\/neu transgenic mice,\u201d Int. J. Cancer, vol. 101, no. 1, pp. 7\u201310, 2002. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12209581\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. N. Anisimov, V. K. Khavinson, I. N. Alimova, A. V. Semchenko, and A. I. Yashin, \u201cEpithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2\/neu mice,\u201d Bull. Exp. Biol. Med., vol. 134, no. 2, pp. 187\u2013190, Aug. 2002. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12459848\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, \u201cGeroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens,\u201d Bull. Exp. Biol. Med., vol. 145, no. 4, pp. 472\u2013477, Apr. 2008. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19110597\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>S. Gery, N. Komatsu, L. Baldjyan, A. Yu, D. Koo, and H. P. Koeffler, \u201cThe circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells,\u201d Mol. Cell, vol. 22, no. 3, pp. 375\u2013382, May 2006. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16678109\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. K. Khavinson, L. K. Shataeva, and A. A. Chernova, \u201cEffect of regulatory peptides on gene transcription,\u201d Bull. Exp. Biol. Med., vol. 136, no. 3, pp. 288\u2013290, Sep. 2003. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14666197\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>O. V. Korkushko et al., \u201c[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people],\u201d Adv. Gerontol. Uspekhi Gerontol., vol. 20, no. 1, pp. 74\u201385, 2007. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17969590\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><li>V. Khavinson, M. Razumovsky, S. Trofimova, R. Grigorian, and A. Razumovskaya, \u201cPineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa,\u201d Neuro Endocrinol. Lett., vol. 23, no. 4, pp. 365\u2013368, Aug. 2002. [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12195242\" target=\"_blank\" rel=\"nofollow noopener\">PubMed<\/a>]<\/li><\/ol><p><strong>ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATONAL AND EDUCATIONAL PURPOSES ONLY.<\/strong><\/p><p>The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.\u00a0 These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.\u00a0 Bodily introduction of any kind into humans or animals is strictly forbidden by law.<\/p><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1048950752\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1048950752\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-42bf8b5 e-flex e-con-boxed e-con e-child\" data-id=\"42bf8b5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c36076d elementor-widget elementor-widget-image\" data-id=\"c36076d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"791\" height=\"1024\" src=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1-791x1024.png\" class=\"attachment-large size-large wp-image-257\" alt=\"\" srcset=\"https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1-791x1024.png 791w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1-232x300.png 232w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1-768x994.png 768w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1-600x777.png 600w, https:\/\/md.biovantixlab.com\/wp-content\/uploads\/2025\/12\/Epitalon_lot_VI520250805-50-1.png 927w\" sizes=\"(max-width: 791px) 100vw, 791px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-1048950753\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-1048950753\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-974752e e-flex e-con-boxed e-con e-child\" data-id=\"974752e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83b86b7 elementor-widget elementor-widget-text-editor\" data-id=\"83b86b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h4>Storage Instructions:<\/h4><p>All of our products are manufactured using the\u00a0<strong>Lyophilization (Freeze Drying)<\/strong>\u00a0process, which ensures that our products remain\u00a0<strong>100% stable for shipping<\/strong>\u00a0for up to\u00a0<strong>3-4 months<\/strong>.<br \/>Once the peptides are\u00a0<strong>reconstituted (mixed with bacteriostatic water)<\/strong>, they must be\u00a0<strong>stored in the fridge<\/strong>\u00a0to maintain stability. After reconstitution, the peptides will remain\u00a0<strong>stable for up to 30 days<\/strong>.<\/p><p>Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you&#8217;re ready to reconstitute it with bacteriostatic water.<\/p><p>Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4C (39F) is generally acceptable.\u00a0Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.<\/p><p>However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80C (-112F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide\u2019s stability.<\/p><p>For further information on proper storage techniques,\u00a0click\u00a0the link below:<\/p><p><blockquote class=\"wp-embedded-content\" data-secret=\"4rYVpTePvZ\"><a href=\"https:\/\/biovantixlab.com\/peptide-storage\/\">Peptide Storage<\/a><\/blockquote><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"&#8220;Peptide Storage&#8221; &#8212; BioVantix\" src=\"https:\/\/biovantixlab.com\/peptide-storage\/embed\/#?secret=6QBPPCrFLf#?secret=4rYVpTePvZ\" data-secret=\"4rYVpTePvZ\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Epitalon (Epithalon) is a research peptide consisting of a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the naturally occurring thymic peptide Epithalamin. Preclinical research has shown that it may influence telomerase activation, oxidative regulation, and circadian gene expression through modulation of pineal peptide signaling pathways. Epitalon is used as a model compound in studies investigating genomic stability, epigenetic regulation, and neuroendocrine peptide signaling.<\/p>\n<p>For research use only. Not for human consumption.<\/p>\n<p><strong>References:<\/strong><br \/>\nKhavinson VK et al., <em>Bulletin of Experimental Biology and Medicine<\/em>, 2003;135(4):429\u2013432<br \/>\nKhavinson VK et al., <em>Biogerontology<\/em>, 2007;8(3):305\u2013313<br \/>\nAnisimov VN et al., <em>Neuro Endocrinology Letters<\/em>, 2003;24(3\u20134):233\u2013240<\/p>\n","protected":false},"featured_media":1694,"template":"","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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(Epithalon) is a research peptide consisting of a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the naturally occurring thymic peptide Epithalamin. Preclinical research has shown that it may influence telomerase activation, oxidative regulation, and circadian gene expression through modulation of pineal peptide signaling pathways. Epitalon is used as a model compound in studies investigating genomic stability,&hellip;","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/product\/1051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/types\/product"}],"version-history":[{"count":3,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/product\/1051\/revisions"}],"predecessor-version":[{"id":1695,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/product\/1051\/revisions\/1695"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=\/wp\/v2\/media\/1694"}],"wp:attachment":[{"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1051"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=1051"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=1051"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/md.biovantixlab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=1051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}